Genetic Basis of Complex Diseases in African Americans : The Black Women’s Health Study

Edward-Ruiz-Narvaez

This Wednesday, May 1st join Epidemiology Faculty Candidate Edward A. Ruiz-Narvaez, Sc.D. as he describes research from the Black Women’s Health Study (BWHS), an ongoing prospective cohort of 59,000 U.S. black women initiated in 1995.

BWHS genetic studies include assessment of susceptibility of breast cancer subtypes, gene-environment interaction in relation to obesity and type 2 diabetes (T2D), admixture mapping of uterine leiomyomata, the major histocompatibility complex and risk of systemic lupus erythematosus, and risk factors for sarcoidosis. Fine-mapping studies in the BWHS of GWAS breast cancer loci have helped to narrow the potential functional locus at chromosome 16q12, identified a novel SNP at chromosome 6q25, and replicated associations with triple negative breast cancer that is most common in African American women. Obesity and T2D occur disproportionately among African American women. Although a westernized lifestyle (low physical activity and energy-dense diets) is the major cause driving the obesity epidemic, it is clear that some individuals with the same lifestyle are more prone than others to develop obesity. Various factors such as perinatal events and chronic stressors may alter the functioning of the neuroendocrine system, resulting in weight gain and the subsequent development of T2D.

This talk will take place in SPH I, Room 1655 from 12-1 PM. For more information, visit here.

 

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